HRX 2024 AbstracX Library-Outcomes of Atrial Fibrillation in Patients with Adrenal Insufficiency: A Population Based Study

Outcomes of Atrial Fibrillation in Patients with Adrenal Insufficiency: A Population Based Study

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The study led by Dr. Nadhem Abdallah investigated the impact of adrenal insufficiency (AI) on patients admitted for atrial fibrillation (AF), using data from the 2016-2019 Nationwide Inpatient Sample. This research addresses the previously under-explored link between AI, cardiovascular disease, and its implications on AF outcomes.<br /><br />The study's primary focus was on the mortality rate of patients, while secondary outcomes included the use of vasopressors and/or mechanical ventilation, length of hospital stay (LOS), and total hospitalization charges (THC). Multivariate linear and logistic regression models adjusted for various factors such as age, race, comorbidities, hospital characteristics, and sex were employed to analyze the data.<br /><br />Key findings suggest that AF patients with AI experience significantly worse outcomes compared to those without AI. Specifically, AI was linked with a higher mortality rate (adjusted odds ratio (aOR) of 2.29), increased use of vasopressors and/or mechanical ventilation (aOR of 2.54), and extended resource utilization with higher hospitalization charges ($62,347 compared to $41,627). Additionally, these patients had a longer mean LOS (4.4 days vs. 3.2 days).<br /><br />The conclusions highlight that AI patients admitted with AF face an elevated risk of in-hospital mortality and non-fatal adverse outcomes, as well as increased healthcare resource consumption. These findings underscore the need for further research to understand the underlying mechanisms at play and to enhance patient care strategies for those with concurrent AI and AF.

Keywords

adrenal insufficiency

atrial fibrillation

mortality rate

vasopressors

mechanical ventilation

hospitalization charges

length of hospital stay

cardiovascular disease

healthcare resource consumption

patient care strategies