HRX 2024 AbstracX Library-Evaluation of Long-term Cardiovascular Risks in ENDS Users

Evaluation of Long-term Cardiovascular Risks in ENDS Users

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The study led by Dr. Matthew M. Kalscheur examines the long-term cardiovascular risks associated with electronic nicotine delivery systems (ENDS) users, using ECG-AI models to predict heart failure and fatal coronary heart disease (CHD). Conducted as part of the CLUES study, it builds on research that explored acute cardiovascular and pulmonary impacts in long-term users. The study highlighted acute worsening of cardiovascular and pulmonary indices following product challenges, prompting an investigation into ECG-AI models as potential biomarkers for long-term cardiovascular risk.<br /><br />The research involved 450 participants, divided into three groups: cigarette users, nicotine vapers (ENDS users), and non-users, with respective average ages of 42.8, 27.4, and 30.8 years. The study utilized 12-lead ECG data from prior studies by Akbilgic and Butler to assess the risks involved.<br /><br />Findings from this investigation indicate that ENDS users face a significantly higher risk of fatal CHD compared to non-users, while the risk of heart failure is notably higher in cigarette users. The ECG-AI models prove promising as indicators of increased cardiovascular risk, suggesting a need for future research in this area.<br /><br />The disclosed conflict of interest in the study involves Dr. Akbilgic, co-founder of 91AI, LLC, while other authors reported no industry relationships. The study underscores the potential of ECG-AI models in predicting cardiovascular risks among ENDS users and supports continued research focusing on the long-term health implications of vaping and traditional smoking.

Keywords

cardiovascular risks

electronic nicotine delivery systems

ECG-AI models

heart failure

coronary heart disease

CLUES study

nicotine vapers

biomarkers

91AI LLC

long-term health implications